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Metabolic Syndrome Linked to Urinary Tract Symptoms

Younger men more likely to have mild-to-severe symptoms such as voiding problems

FRIDAY, July 24 (HealthDay News) -- Younger men with lower urinary tract symptoms are significantly more likely to exhibit metabolic syndrome than men without urinary tract symptoms, according to a study published in the August issue of the Journal of Urology.

Varant Kupelian, Ph.D., of the New England Research Institutes in Watertown, Mass., and colleagues recruited 2,301 men ages 30 to 79 years and assessed 1,899 subjects who provided blood samples.

Compared to men with an American Urological Association symptom index score of zero or one, the researchers found that those with mild to severe symptom scores (two to 35) were significantly more likely to have metabolic syndrome (multivariate odds ratio, 1.68). They also found that metabolic syndrome was significantly associated with voiding symptom scores of at least five (multivariate adjusted odds ratio, 1.73), and increased odds of metabolic syndrome were seen even with mild symptoms such as incomplete emptying, intermittency and nocturia. They primarily observed these associations in men under the age of 60 years.

"The observed association between urological symptoms and the metabolic syndrome provides further evidence of common underlying factors between lower urinary tract symptoms and chronic conditions outside the urinary tract," the authors conclude.

The study was supported by Pfizer Inc., and several authors reported financial relationships with Pfizer and other pharmaceutical companies.

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