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Metabolic Syndrome Linked to Prostate-Specific Antigen

Prostate-specific antigen levels are influenced by a number of factors unrelated to prostate cancer

WEDNESDAY, Oct. 1 (HealthDay News) -- Prostate-specific antigen (PSA) levels are influenced by both age and components of the metabolic syndrome, according to study findings published in the October issue of Urology.

June Hyun Han, M.D., Ph.D., of Hanil General Hospital in Seoul, Korea, and colleagues examined the relationships between PSA levels and age, body mass index, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol and fasting blood glucose, in order to determine factors predictive of the serum PSA level among men with a low risk of prostate cancer. Overall, 38,356 healthy male employees of the Korea Electric Power Corporation who were less than 60 years old with a serum PSA level of less than 4 ng/mL were included.

On average, participants were 44 years old with mean serum PSA levels of 0.89 ng/mL, and an incidence of metabolic syndrome of 25.8 percent, the investigators found. In univariate analysis, PSA was significantly correlated with body mass index, diastolic blood pressure, HDL and fasting blood glucose. In multiple logistic regression analyses, serum PSA levels were positively associated with older age and diastolic blood pressure, while body mass index, HDL and fasting blood glucose were negatively correlated with the serum PSA level, the researchers report.

"These observations suggest that the metabolic syndrome reflects a state of low-circulating testosterone, which in turn influences the serum PSA concentration," the authors conclude.

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