Obesity a Predictor of Prostate Cancer Recurrence

Cancer registry shows that obese at greater recurrence risk after radical prostatectomy

MONDAY, Nov. 28 (HealthDay News) -- Men who are obese and undergo radical prostatectomy have a greater risk of cancer recurrence than their leaner counterparts, according to data from CaPSURE, a registry of 10,018 men with prostate cancer. The findings are published in the November issue of Urology.

A team from the University of California at San Francisco, led by William W. Bassett, M.D., followed patients for a median of 23 months. Of the 2,131 men who underwent radical prostatectomy in CaPSURE, 251 men, or 12%, had disease recurrence at 13 months. Disease recurrence was defined as a PSA level of 0.2 ng/mL or greater or any second treatment. The investigators adjusted for risk group (PSA level, Gleason grade and clinical T stage), ethnicity, age and comorbidities.

Patients with a body mass index (BMI) of 35 kg/m2 or greater were 1.69 times more likely to have disease recurrence compared with men with BMIs less than 25 kg/m2. Other risk factors were increasing PSA level and increasing Gleason scores.

"Because of the increased comorbidities and greater rates of recurrence, obese individuals undergoing radical prostatectomy need vigilant follow-up care," the authors conclude.

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