See What HealthDay Can Do For You
Contact Us

PSA Failure Predicts Death in Men With No, Minimal Comorbidity

Findings among men with localized intermediate- and high-risk prostate cancer

prostate cancer

THURSDAY, Sept. 8, 2016 (HealthDay News) -- Prostate-specific antigen (PSA) failure is associated with increased risk of all-cause mortality for men with intermediate- or high-risk prostate cancer with no or minimal comorbidity, according to a study published online Sept. 6 in the Journal of Clinical Oncology.

Nicholas J. Giacalone, M.D., from Brigham and Women's Hospital in Boston, and colleagues examined whether PSA failure is associated with the risk of all-cause mortality stratified by comorbidity score. Two hundred six men with localized intermediate- and high-risk prostate cancer were randomized to receive radiation therapy or radiation therapy and six months of androgen deprivation therapy.

After a median follow-up of 16.62 years, the researchers found that 76 percent of the men died, and 19 percent of those men died as a result of prostate cancer. Among men with no or minimal comorbidity, PSA failure was associated with an increased risk of all-cause mortality (adjusted hazard ratio, 1.59; 95 percent confidence interval, 1.03 to 2.46; P = 0.04); this was not the case for men with moderate or severe comorbidity (adjusted hazard ratio, 1.75; 95 percent confidence interval, 0.76 to 3.99; P = 0.19).

"Recommending treatment on the basis of reduced PSA failure observed from early results of randomized controlled trials is unlikely to prolong survival in men with moderate-to-severe comorbidity but may prolong survival in men with no or minimal comorbidity, providing evidence to support discussing the early results with these men," the authors write.

One author disclosed financial ties to the biopharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.