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Depression, Benign Prostatic Hyperplasia Linked

Those with depression have more severe symptoms; causality unclear

TUESDAY, Dec. 28 (HealthDay News) -- A significant association between the occurrence of depression and benign prostatic hyperplasia (BPH) has been found, although it is not clear whether unidirectional or bidirectional causality exists, according to a report published in the December issue of Urology.

Timothy V. Johnson, M.D., of the Emory University School of Medicine in Atlanta, and colleagues studied 547 male urology patients aged 40 and older, who completed the Geriatric Depression Scale and the American Urological Association Symptom Index (AUA-SI), to evaluate the connection between depression and the severity of symptoms. The patients were 49 percent black/African-American and 44 percent white/Caucasian. The AUA-SI was used to determine the severity of BPH symptoms.

The researchers found that 22 percent of the patients screened positive for depression. Patients with depression self-reported significantly higher AUA-SI scores, and more than two-thirds presented with moderate or severe AUA-SI symptoms. After adjusting for age, education level, income, race, native language, employment, and homeless status, patients with depression were found to be three times more likely to present with severe symptoms. The researchers were not able to determine whether the relationship between depression and BPH had unidirectional or bidirectional causality.

"Our findings suggest a significant association between depression and BPH, as measured by the AUA-SI score. The depressed patients reported mean AUA-SI scores almost 156 percent greater than did the nondepressed patients," the authors write.

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