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Tadalafil Aids Erectile Function After Spinal Cord Injury

Study subjects report more successful attempts at penetration and intercourse

FRIDAY, Oct. 12 (HealthDay News) -- Men with traumatic spinal cord injuries who take tadalafil experience significantly improved erectile function, researchers report in the October Archives of Neurology.

Francois Giuliano, M.D., Ph.D., of the Raymond Poincare Hospital in Garches, France, and colleagues randomly assigned 186 men (mean age 38 years) with traumatic spinal cord injuries and histories of erectile dysfunction (ED) to 12-week on-demand doses of either tadalafil, maintained or titrated at 10 or 20 mg, or placebo. Results were determined by subject response to questions included in the International Index of Erectile Function, the Sexual Encounter Profile and the Global Assessment Question.

Compared to the placebo group, the tadalafil group reported significantly greater percentages of successful penetration attempts, successful intercourse attempts, improved erections and ejaculatory frequency. Side effects, including headache and urinary tract infection, were reported in less than 10 percent of treatment subjects.

"As in other ED studies that include patients who were difficult to treat owing to preexisting conditions (e.g., prostatectomy, diabetes mellitus), tadalafil was efficacious for the treatment of ED after a traumatic spinal cord injury," the authors conclude.

Giuliano is a consultant for Eli Lilly, which sells tadalafil under the brand name Cialis. Other members of the study team are employees of Eli Lilly, and Lilly ICOS LLC provided funding for the study.

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