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AUA: Nocturia Linked to Increased Risk of Mortality

Association exists even after adjustment for several factors that could contribute to mortality

MONDAY, May 31 (HealthDay News) -- Patients of all ages with nocturia -- two or more episodes of urination per night -- may have an increased risk of mortality, according to two studies presented at the annual meeting of the American Urological Association, held from May 29 to June 3 in San Francisco.

In one study, Varant Kupelian, Ph.D., of the New England Research Institutes in Watertown, Mass., and colleagues analyzed data from the Third National Health and Nutrition Examination Survey on a sample of 15,988 men and women ages 20 and older. Their analyses showed the greatest associations between nocturia and mortality in adults under age 50 and between ages 50 to 64, and attenuated but statistically significant associations in those ages 65 and older.

In a related study, Japanese researchers assessed 788 adults ages 70 to 97. Compared to subjects who voided one or fewer times per night, they found that those who voided two, three, and at least four times per night had an increased risk of mortality (hazard ratios, 1.59, 2.34, and 3.60, respectively).

"There is a significantly increased mortality associated with the nighttime frequency of urination, even after adjustment for several factors that could contribute to mortality," conclude the authors of the second study.

The first study was partly supported by a grant from Ferring Pharmaceuticals.

Abstract No. 56 - Kupelian
Abstract No. 3 - Nakagawa

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