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August 2012 Briefing - Urology

Here are what the editors at HealthDay consider to be the most important developments in Urology for August 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Colpocleisis Deemed Safe for Advanced Pelvic Organ Prolapse

FRIDAY, Aug. 31 (HealthDay News) -- Colpocleisis is a safe and effective treatment for advanced pelvic organ prolapse; however, urinary frequency and urgency often persist after the procedure, according to research published in the September issue of Urology.

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Kidney Stones Increase Risk of Adverse Kidney Outcomes

FRIDAY, Aug. 31 (HealthDay News) -- Kidney stones correlate with an increased risk of adverse kidney outcomes, including end-stage renal disease (ESRD), stage 3b to 5 chronic kidney disease, and sustained doubling of serum creatinine, but increases in absolute rates are small, according to a study published online Aug. 30 in BMJ.

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Nutrient Intake Reduces Sperm DNA Damage in Older Men

THURSDAY, Aug. 30 (HealthDay News) -- Older men who consume higher amounts of certain micronutrients such as vitamin C, vitamin E, and zinc have less DNA damage to their sperm, according to a study published online Aug. 28 in Fertility and Sterility.

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Lower Prostate Cancer-Specific Death With Anticoagulant Use

THURSDAY, Aug. 30 (HealthDay News) -- Anticoagulant (AC) therapy, particularly aspirin, is associated with a reduced risk of prostate cancer-specific mortality (PCSM) among men treated with radical prostatectomy (RP) or radiotherapy (RT), according to a study published online Aug. 27 in the Journal of Clinical Oncology.

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Cetuximab, Paclitaxel Combo Active in Urothelial Cancer

WEDNESDAY, Aug. 29 (HealthDay News) -- The monoclonal antibody against epidermal growth factor receptor (EGFR), cetuximab, augments the antitumor activity of paclitaxel in patients with previously treated urothelial cancer, according to a study published online Aug. 27 in the Journal of Clinical Oncology.

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AAP: Health Benefits of Male Circumcision Outweigh Risks

MONDAY, Aug. 27 (HealthDay News) -- The health benefits of circumcision for newborn males outweigh the risks, according to a policy statement from the American Academy of Pediatrics (AAP) published online Aug. 27 in Pediatrics.

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Improved Survival for Prostate Cancer Seen in Post-PSA Era

MONDAY, Aug. 27 (HealthDay News) -- Overall survival for metastatic prostate cancer is significantly improved in a post-prostate-specific antigen (PSA) era trial compared with two trials conducted before the PSA era, according to research published online Aug. 23 in The Journal of Urology.

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RNA Assays Up Sensitivity of Urothelial Carcinoma Detection

TUESDAY, Aug. 21 (HealthDay News) -- Cxbladder, a derivative of the RNA assay uRNA, may be an effective alternative to cytology and nuclear matrix protein 22 (NMP22) assays for the detection of urothelial carcinoma, according to a study published in the September issue of The Journal of Urology.

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De Novo Mutation Rate Higher in Children of Older Fathers

WEDNESDAY, Aug. 22 (HealthDay News) -- Children of older fathers have a higher rate of new mutations, which may affect the risk of diseases such as autism and schizophrenia, according to a study published in the Aug. 23 issue of Nature.

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Process Areas for Improvement ID'd in Early Prostate Cancer

WEDNESDAY, Aug. 22 (HealthDay News) -- For men with early prostate cancer undergoing expectant management, compliance with RAND structural indicators is high, but there is considerable variability in compliance with process indicators, according to a study published in the September issue of The Journal of Urology.

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2012 Indicators of Well-Being for Older Americans Issued

MONDAY, Aug. 20 (HealthDay News) -- The estimates of selected indicators for well-being for older Americans for 2012 have been released by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics.

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Small-Molecule Inhibitor Has Potential As Male Contraceptive

THURSDAY, Aug. 16 (HealthDay News) -- In mice, a selective, small-molecule inhibitor, JQ1, which targets the testis-specific member of the bromodomain and extraterminal subfamily of epigenetic reader proteins, BRDT, can cross the blood:testis barrier and cause complete and reversible contraception in mice, according to a study published online Aug. 16 in Cell.

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Enzalutamide Prolongs Survival in Resistant Prostate Cancer

THURSDAY, Aug. 16 (HealthDay News) -- Men with metastatic castration-resistant prostate cancer after chemotherapy have improved survival and secondary end points after treatment with enzalutamide versus placebo, according to a study published online Aug. 15 in the New England Journal of Medicine.

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Benefit of PSA Reduced by Loss of Quality-Adjusted Life-Years

WEDNESDAY, Aug. 15 (HealthDay News) -- Although the European Randomized Study of Screening for Prostate Cancer (ERSPC) has reported a 29 percent reduction in prostate-cancer mortality for men who undergo prostate-specific antigen (PSA) screening, the benefit is attenuated by loss of quality-adjusted life-years (QALYs) due to post-diagnosis effects, according to a study published in the Aug. 16 issue of the New England Journal of Medicine.

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Kidney Donors, Recipients Have Little Difference in Income

TUESDAY, Aug. 14 (HealthDay News) -- The median income differences between living kidney donors and transplant recipients in the United States are negligible, according to a study published online Aug. 6 in the American Journal of Transplantation.

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Poor Follow-Up of Hospital Tests Often Due to Late Orders

TUESDAY, Aug. 14 (HealthDay News) -- Poor follow-up of test results at or after discharge from the hospital is often due to tests requested on the day of discharge, according to a letter to the editor published online Aug. 13 in the Archives of Internal Medicine.

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Supplement Doses Inadequate for Androgen Deprivation Therapy

MONDAY, Aug. 13 (HealthDay News) -- Currently recommended calcium and vitamin D supplementation doses are inadequate to prevent bone mineral density (BMD) loss in men undergoing androgen deprivation therapy (ADT) for prostate cancer, according to a study published online July 25 in The Oncologist.

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High-Risk HPV Present in Subset of Penile Carcinomas

MONDAY, Aug. 13 (HealthDay News) -- High-risk human papillomavirus (hrHPV) infection is found in a subset of penile squamous cell carcinomas (PSCCs) that may develop from undifferentiated penile intraepithelial neoplasia (PeIN), according to a study published online Aug. 6 in the Journal of the American Academy of Dermatology.

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PSA Change After 5α Reductase Therapy Aids Cancer Diagnosis

FRIDAY, Aug. 10 (HealthDay News) -- The magnitude of change in serum prostate specific antigen (PSA) after 5α-reductase inhibitor therapy may help diagnose prostate cancer in men with persistently increased serum PSA and previously negative biopsies, according to a study published in the September issue of The Journal of Urology.

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After Bariatric Op, Controlled Diet Can Aid CaOx Supersaturation

THURSDAY, Aug. 9 (HealthDay News) -- After bariatric surgery, following a diet that is normal in calcium, low in oxalate, and moderate in protein, can improve urinary calcium oxalate (CaOx) supersaturation, but not urinary oxalate excretion, in patients with a history of kidney stones, according to a study published in the August issue of Urology.

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'Surgeon-Tailored' Mesh Repair Resolves Urinary Incontinence

THURSDAY, Aug. 9 (HealthDay News) -- "Surgeon-tailored" polypropylene mesh (STPM) repair using a transobturator midurethral sling procedure alone or in combination with pelvic organ prolapse repair is an effective treatment for stress urinary incontinence symptoms, although some concerns remain regarding mesh-related complications, according to a study published in the August issue of Urology.

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Vulvodynia Linked to Other Chronic Pain Conditions

MONDAY, Aug. 6 (HealthDay News) -- Women with vulvodynia are approximately two to three times more likely to have a comorbid chronic pain condition such as fibromyalgia, interstitial cystitis, or irritable bowel syndrome, according to research published in the July issue of Obstetrics & Gynecology.

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Larger Waist Linked to Worse Voiding Function in Men

FRIDAY, Aug. 3 (HealthDay News) -- Central obesity, as measured by waist circumference (WC), is associated with worse voiding, and men with a higher WC may be at increased risk of male pelvic dysfunction, according to a study published in the August issue of BJU International.

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Clinicians Can Unintentionally Prompt Nocebo Effect

THURSDAY, Aug. 2 (HealthDay News) -- The nocebo effect, or induction of a symptom perceived as negative by sham treatment and/or the suggestion of negative expectation, may arise from suggestions by doctors and nurses, according to a study published in Deutsches Ärzteblatt International.

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Men With Prostate Cancer Increasingly Don't Die From It

WEDNESDAY, Aug. 1 (HealthDay News) -- Men diagnosed with prostate cancer are more likely to die from other conditions, including heart disease, than from prostate cancer, according to a study published online July 25 in the Journal of the National Cancer Institute.

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Active Surveillance Up in Multidisciplinary Prostate CA Care

WEDNESDAY, Aug. 1 (HealthDay News) -- Men with low-risk prostate cancer are more likely to pursue active surveillance when seen at a multidisciplinary prostate cancer clinic rather than when they see individual specialists in sequential settings, according to a study published online July 30 in the Journal of Clinical Oncology.

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