Periurethral Collagen Injections Help Incontinence

Mixed urinary incontinence patients at risk from surgical or medical side effects may benefit most

THURSDAY, April 20 (HealthDay News) -- Periurethral collagen injections increase the quality of life for patients with mixed urinary incontinence and may reduce their need for anticholinergic medications, according to a study in the April issue of Urology.

Christina I. Poon, M.D., of the University of Texas Southwestern Medical Center in Dallas, and a colleague reviewed data on 56 mixed urinary incontinence patients primarily treated with periurethral collagen injections between February 1999 and February 2003.

After a mean 18-month follow-up, the researchers found that patients reported that their quality of life had improved. In addition, fewer patients were taking anticholinergic medications.

"The use of periurethral collagen injection as the primary/initial intervention in patients with mixed urinary incontinence may be the preferred approach, particularly in patients with an elevated risk of anticholinergic medication side effects or when voiding dynamics preclude sling placement," the authors write.

In an editorial, J. Christian Winters, M.D., of Ochsner Clinic in New Orleans, writes that the results "are encouraging and introduce early data demonstrating the potential benefits of injections in women with mixed urinary incontinence. However, it seems clear, given the limited efficacy data available in women with mixed urinary incontinence, that a comprehensive evaluation and individualized management is necessary to achieve optimal outcomes."

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