September 2007 Briefing - Urology

Here are what the editors at HealthDay consider to be the most important developments in Urology for September 2007. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Location More Important Than Number in Prostate Biopsies

FRIDAY, Sept. 28 (HealthDay News) -- Post-mortem prostate biopsies reveal that biopsy site is more important in the successful detection of tumors than the number of biopsy cores taken, researchers report in the Oct. 3 issue of the Journal of the National Cancer Institute.

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Medications, Diet May Help Prevent Prostate Cancer

MONDAY, Sept. 24 (HealthDay News) -- During the past 15 years, prostate cancer prevention has become a major area of scientific and clinical investigation, and ongoing studies may soon identify effective chemoprevention strategies, according to a report published online Sept. 24 in the journal Cancer.

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Prostatectomy Helps Survival If Lymph Nodes Positive

FRIDAY, Sept. 21 (HealthDay News) -- Radical prostatectomies performed during the prostate-specific antigen (PSA) screening era on men with lymph node-positive prostate cancer are associated with good long-term survival rates, according to a report in the September issue of the Journal of Urology.

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Gene Variation Linked to Greater Risk of Scleroderma

THURSDAY, Sept. 20 (HealthDay News) -- The G-945C polymorphism in the connective-tissue growth factor gene is strongly associated with systemic sclerosis, making it a candidate gene for scleroderma, according to study findings published in the Sept. 20 issue of the New England Journal of Medicine.

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Poor Outcomes for Spina Bifida Patients with Bladder Cancer

THURSDAY, Sept. 20 (HealthDay News) -- Many patients with spina bifida who develop bladder cancer do so at a relatively young age with an advanced-stage disease at diagnosis, researchers report in the September issue of the Journal of Urology.

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Urethral Strictures Associated with Early Urinary Retention

WEDNESDAY, Sept. 19 (HealthDay News) -- Men who develop early urinary retention after radical prostatectomy are more likely to develop a symptomatic urethral stricture, according to a prospective database report published in the August issue of Urology.

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Medical Schools Vary in Approach to Case Reports

WEDNESDAY, Sept. 19 (HealthDay News) -- Most medical school institutional review boards (IRBs) don't treat individual case reports as "research," as it's defined by the United States Government Code of Federal Regulations, according to a research letter published in the Sept. 19 issue of the Journal of the American Medical Association.

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Sleep Positions May Influence Development of Kidney Stones

WEDNESDAY, Sept. 19 (HealthDay News) -- The positions in which people sleep affect the degree of blood perfusion in their kidneys, which may in turn influence their development of kidney stones, according to a report in the August issue of Urology.

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Nocturnal Hemodialysis Improves Cardiac Health

WEDNESDAY, Sept. 19 (HealthDay News) -- Dialysis patients randomized to receive hemodialysis six nights a week experienced improvements in left ventricular mass, blood pressure and select measures of quality of life compared to those undergoing conventional hemodialysis, researchers report in the Sept. 19 issue of the Journal of the American Medical Association.

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Protein Predicts Skeletal Events in Prostate Cancer

TUESDAY, Sept. 18 (HealthDay News) -- Men with metastatic prostate cancer are at greater risk of skeletal complications when they have elevated levels of serum bone-specific alkaline phosphatase (BAP), researchers report in the August issue of Urology.

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Excellent Long-Term Outcomes for Testis-Sparing Surgery

TUESDAY, Sept. 18 (HealthDay News) -- Testis-sparing surgery for Leydig cell tumors results in an excellent long-term outcome in terms of survival, according to a report in the September issue of the Journal of Urology.

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Anxiety Influences Treatment Decision in Prostate Cancer

TUESDAY, Sept. 18 (HealthDay News) -- Feelings of anxiety can spur prostate cancer patients to decide to move from surveillance to treatment as much as changes in prostate specific antigen values, according to the results of a study published in the September issue of the Journal of Urology.

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Nasal Surgery Feminizes Transsexuals' Facial Profiles

MONDAY, Sept. 17 (HealthDay News) -- In male-to-female transsexuals, nasal feminization surgery may play an important role in the gender reassignment process, researchers report in the September/October issue of the Archives of Facial Plastic Surgery.

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Interstitial Cystitis Patients Often Have History of Abuse

MONDAY, Sept. 17 (HealthDay News) -- Patients with interstitial cystitis are more likely to report histories of abuse than other patients, researchers report in the September issue of the Journal of Urology.

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Finasteride May Not Induce High-Grade Prostate Cancer

FRIDAY, Sept. 14 (HealthDay News) -- The increased rate of high-grade prostate cancer associated with finasteride reported in the Prostate Cancer Prevention Trial (PCPT) is likely due to detection bias rather than finasteride-induced stimulation of high-grade tumors, according to two studies published online Sept. 11 in the Journal of the National Cancer Institute.

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Micronutrients Do Not Reduce Prostate Cancer Risk

THURSDAY, Sept. 13 (HealthDay News) -- Despite the fact that low blood concentrations of micronutrients such as carotenoids, retinol and tocopherols have been associated with increased risk of prostate cancer, there is no evidence that they protect against the disease, according to a study in the September issue of the American Journal of Clinical Nutrition.

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One in Three Needle Biopsies Detect Prostate Cancer

THURSDAY, Sept. 13 (HealthDay News) -- Prostate cancer is detected in one-third of men undergoing a needle biopsy of the prostate, and those with negative biopsies often undergo repeat biopsies, leading to a higher likelihood of finding cancer, according to research published online Sept. 11 in the Journal of the National Cancer Institute.

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Tadalafil Improves Sexual Function After Spinal Injury

TUESDAY, Sept. 11 (HealthDay News) -- Men with spinal cord injury are more likely to have erections and engage in sexual activity if they use 10 or 20 milligrams of tadalafil, according to research published online Sept. 10 in the Archives of Neurology.

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Supplement Recalled Due to Undeclared Sildenafil

TUESDAY, Sept. 11 (HealthDay News) -- The U.S. Food and Drug Administration has announced the recall of a dietary supplement known as Zencore Tabs due to the presence of analogs of the erectile dysfunction drugs tadalafil and sildenafil. These undeclared ingredients may interact with nitrates found in prescription drugs, such as nitroglycerin.

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Potential Sperm Stem Cell Niche Identified

THURSDAY, Sept. 6 (HealthDay News) -- Scientists have discovered that sperm stem cells cluster around blood vessel branch points in the testes of mice, and may be a potential "microenvironmental niche," according to a study published online Sept. 6 in Science.

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Receptor Gene May Play Key Role in Urinary Tract Infections

THURSDAY, Sept. 6 (HealthDay News) -- Susceptibility to acute pyelonephritis may have a genetic element, with the IL-8 receptor gene, CXCR1, a leading candidate, according to study findings published in the September issue of PLoS ONE.

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